Department of Critical Care Medicine

Research

Overview

The Department of Critical Care Medicine is involved in research through post graduate dissertations, investigator originated projects, educational research, multicenter research projects both national and international and sponsored clinical trials.

The dedicated researchers of the Critical Care Medicine department are committed to conducting innovative and high-impact research across the spectrum of critical care research ranging from basic science to clinical trials. They focus on researching new diagnostic options to improve the outcomes for critically ill patients. They also provide supportive research services to investigators.

Research Events

The Department of Critical Care Medicine has participated in a solidarity trial and contributed to several clinical trials and studies at national and international levels to promote groundbreaking research.

Participation and Contribution

Participated as center for ICMR WHO SOLIDARITY trial.

Contributed to many multicenter clinical trials and studies such as

National Level:

The Physiology Department has an M.C.I. recognized postgraduate (M.D.) department where 14 students have completed post-graduation so far.

INDICAPS I & II,
AQCH trial in COVID,
ISCCM Pune- PICASO study,
IPRI Pune – DIMODS study,
ISCCM HERMES trial

International Level:

PRoVENT iMiC,
SCARLET trial
ACME Collaboration studies.
ACT trial (PHRI, Canada)

Contributed to multiple investigator-initiated studies and publications.

Dissertations-

Sr. No	Name of the Students	Topics name
1	Dr. Prashant Jedge	Prospective observational study of high flow nasal oxygen therapy and noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure
2	Dr. Akshay Khare	Evaluation of admission serum magnesium levels in patients with septic shock and its correlation with outcome
3	Dr. Dharanindra	The comparison of kingvision video laryngoscope and Macintosh laryngoscope for endotracheal intubation in the intensive care unit
4	Dr. Kiran Vadapalli	Use of lung and diaphragmatic ultrasound in predicting weaning outcomes in critically ill mechanically ventilated patients
5	Dr. Shambhavi	“A study of ventilator-associated events and their outcome in critically ill patients with prolonged mechanical ventilation”
6	Dr.Nishant Agrawal	“Comparison of full Outline of UnResponsiveness score (four Score) and Glasgow coma pupil Score (GCS-p score) on admission in predicting the outcome in patients with traumatic brain injury in intensive care unit
7	Dr. Venkatesh Satri	A prospective observational study of renal replacement therapy in intensive care unit in a tertiary care teaching hospital

Publications

The outstanding research works of our faculty and medical students have got published in several peer-reviewed journals. Their works have also earned spaces in several books as textbook chapters.

Research works published in journals

Sr No	Title	Author	Journal	Citation Index	Year
1	Efficacy and safety of a phytopharmaceutical drug derived from Cocculus hirsutus in adult with moderate COVID 19; a Phase 2, Open-label, Multicenter Randomized controlled trial	Sadhna Joglekar,Shivakumar S Iyer, Rohit Parate, Akash A Khobragade, Rakesh Patil, Shashi Bhushan, Dnyanshwar M Halnor, Girish C Rajadhyaksha, Kartikeya Parmar, Shilpi Dhawan, Suyog Mehta, Shashank R Joshi	Infectious Disease Theapeutics	Pubmed	Feb 2022
2	Geoeconomic variations in epidemiology, ventilation management and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies	Jignesh Shah (PRoVENT iMiC study site investigator )	Lancet Global Health Vol 10, issue 2, Feb 2022	Pubmed	Feb 2022
3	Insulin Resistance and Homeostatic Model Assessment in Critically ill- Where Do We stand?	Jignesh Shah	Indian Journal of Critical Care Medicine	Pubmed, SCOPUS	2021
4	Intensive Care In India In 2018-2019: The Second Indian Intensive Care Case Mix And Practice Patterns Study	Jigeeshu Divatia, Yatin Mehta, Deepak Govil etal Dr Jignesh Shah, Dr Prashant Jedge – Site PI	IJCCM Ahead of print	Pubmed SCOPUS	2021
5	Direct Medical Cost Analysis In Indian Covid-19 Patients Requiring Critical Care Admission	Kamini Reddy, Shivakumar Iyer, Monidipa Chowdhury, Naveen Yerrapalem, Neeraja Pasalkar, Prashant Jedge, Jignesh Shah	IJCCM Accepted for publication	Pubmed SCOPUS	2021
6	The utility of a modified technique for lower respiratory tract sampling in COVID-19 ICU and review of diagnostic approaches in suspected ventilator associated pneumonia	Anita Anokar Prashant Jedge, Jignesh Shah Samruddhi Chougale	Critical Care Innovations Accepted for publication	DOAJ	2021
7	Experimental Chest X-ray Scoring System for Determining Patient Outcomes in COVID Patients	Nishant Agrawal, Samruddhi Dhanaji Chougale, Prashant Jedge, S. Iyer	JCDR. Accepted for publication	DOAJ	2021
8	Prospective Observational Study of High Flow Nasal Oxygen Therapy And Non Invasive Positive Pressure Ventilation In Patients With Acute Hypoxemic Respiratory Failure	Prashant Jedge, Jignesh Shah, Sampada Kulkarni, Shivakumar Iyer	Indian Journal of Respiratory Care2012;10:201-5	DOAJ, Emerging Sources Citation Index, Web of Science	2021
9	Running out of vascular access in CKD patients- a case report on translumbar dialysis catheter	Nishant Agrawal, YadavWaghaji Munde, Jignesh Navinchandra Shah, Prajakta Sunil Lanjewar, Sunil Jawale	Indian Journal of Vascular and Endovascular Surgery.	Pubmed	2021
10	Early and high SARS-CoV-2 neutralizing antibodies are associated with severity in COVID-19 patients from India	Shrivastava, Shubham, Palkar, Sonali, Shah, Jignesh, Rane, Prajakta, Lalwani, Sanjay, Mishra, Akhilesh, Arankalle, Vidya	American Journal of Tropical Medicine & Hygiene Doi:10.4269/ajtmh.21-0014	Pubmed	2021
11	Stress levels and its determinants among staff (doctors and nurses) working in critical care unit	Vishwanath Patil, Jignesh shah Shivakumar Iyer	Indian Journal of Critical Care Medicine	Pubmed SCOPUS	2021
12	Off- label drug prescription pattern and related adverse drug reactions in the medical intensive care unit	Asawari Raut,Kavita Krishna, Utkarsha Adake,Apurva Sharma, Anitta Thomas Jignesh Shah	Indian Journal of Critical Care Medicine Accepted for publication	Pubmed	2021
13	Strychnine poisoning- case series of survivors	Venkatesh Satri, Prashant Jedge, Shivakumar S Iyer, Dharanindra Moturu, Jignesh N Shah	Journal of the Indian Society of Toxicology Vol 16, issue 2 ; Jul-Dec 2020	Medline	2021
14	Epidemiological Characteristics Ventilator Management and Clinical Outcome in Patients Receiving Invasive Ventilation in Intensive Care Units from 10 Asian Middle – Income Countries (PRoVENT-iMic): An International Multicenter, Prospective Study	Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Areef Ahsan, Abigail Beane, Kaweesak Chittawatanarat, Abul Faiz, Rashan Haniffa, Seyed Mohammad Reza Hashemian, Madiha Hashmi 8, Hisham Ahmed Imad , KanishkaIndraratna, Shivakumar Iyer, GyanKayastha , Bhuvana Krishna, Tai Li Ling, Hassan Moosa , BehzadNadjm, Rajyabardhan Pattnaik, Sriram Sampath, Louise Thwaites, Ni NiTun, Nor'azimMohd Yunos, Salvatore Grasso, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Nick Day, Nick White, Arjen M Dondorp, Marcus J Schultz, For The PRoVENT-iMiC Investigators Moru And The Prove Network	An International, Multicenter, Prospective Study. Am J Trop Med Hyg. 2021 Jan 11.	Pub Med	Jan 2021
15	Repurposed Antiviral Drugs for Covid-19 —Interim WHO Solidarity Trial Results	N Agrawal, S Iyer, K Reddy, S Rege, J Shah (Site investigators)	The New England Journal of medicine	PubMed	Feb 2021
16	Cost of medical management of patients in intensive care unit in a tertiary care teaching hospital, Pune, India	Achsah Anna Mathew, Jainam Narendra Karsiya, Neel Kiran Patel, Dharmik Anil Limbachiya, Jignesh Navinchandra Shah1, Atmaram P. Pawar2, Prasanna R. Deshpande	MGM J Med Sci 2021;8:268-76.	DOAJ	2021
17	An out of the ordinary case report of ticagrelor furthering rhabdomyolsis induced by atorvastatin	Nishant Agrawal, Shivakumar Iyer, Jignesh Shah, Prashant Jedge	International Journal of Science and Research	ResearchGate Impact Factor (2018): 0.28 \| SJIF (2019): 7.583	2020
18	Dietary Fiber: Is It Hype or Useful?	Shivakumar Iyer	Indian J Crit Care Med 2020 Nov;24(11):1014. doi: 10.5005/jp-journals-10071-23655.	PubMed, SCOPUS	Nov 2020
19	Fractured Guidewire of Hemodialysis Catheter	Prashant Jedge, Jignesh Shah, Shivakumar Iyer, Vishwanath Patil	International Journal Of Scientific Research Volume 9, Issue 8, August 2020	Cross Ref Google scholar Indian Citation Index Index Medicus	Aug 2020
20	Our Experience of Tracheostomy in COVID -19 Patients	Prasun Mishra, Prashant Jedge, Maitri Kaushik, Purva Artham	Indian J Otolaryngol Head Neck Surg https://doi.org/10.1007/s12070-020-02036-z	PubMed, Cross Ref, Google Scholar, PMC free article	Aug 2020
21	Effect of Academic Detailing on Improvement in Venous Thromboembolism Prophylaxis for Critically Ill and Surgical Patients in a Tertiary Care Teaching Hospital	Bijoy Kumar Panda, Vinod Kumar, MN Ketkar1, Jignesh Shah2	Indian Journal of Vascular and Endovascular Surgery Volume 7 Issue 1, Jan – March 2020	Cross Ref, Google Scholar, PubMed	March 2020
22	Evaluation of admission serum magnesium levels in patients with septic shock and its correlation with outcome	Akshay R. Khare, Vishwanath C. Patil, Jignesh N. Shah, Shivakumar S. Iyer	Int. J. Adv. Med.2020 Jan7(1):155-160	Index Copernicus Index Medicus for South-East Asia Region (WHO) ScopeMed Journal Index J-Gate Google Scholar CrossRef Directory of Science	2019
23	Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in patient with Sepsis Associated Coagulopathy The SCARLET Randomized Clinical Trial	Shivakumar S. Iyer Site PI	JAMA 2019 May 28;321(20):1993-2002. doi: 10.1001/jama.2019.5358.	Pub med	2019
24	Review of code blue system and audit	Patil VC, Shah JN, Jedge PP, Patil SV	Int J Res Med Sci. 2019 May;7(5):1809-1812	Index Copernicus Index Medicus for South-East Asia Region (WHO) ScopeMed CrossRef Google Scholar Ulrichsweb Journal Index J-Gate Directory of Science	2019
25	Identification and Assessment of Potential Drug-Drug Interactions in Intensive Care Unit Patients.	Wagh BR, etal, Iyer SS	Indian J Crit Care Med 2019; 23(4):170–174.	PubMed, Pro Quest, EMBASE, Scopus, EBSCO, HINARI, Google Scholar, ESCI	2019
26	Knowledge and attitude regarding organ donation among relatives of patients admitted in ICU	Patil S.V., Ostwal N.B., Patil V.C., Gothankar J.S.	Public health Rev: Int J Public health Res 2019;6(3):89-95.doi:10. 17511/ijphr.2019.i3.01.	Index Copernicus Science central, INDIANScience.in, J-Gate Indexing, Google Scholar	2019
27	Stratification of patients with emergency severity index and effects of its implementation on the outcome in emergency department of tertiary care hospital 2018	Sada EC etal, S. Iyer, J. Shah	International Journal Of Scientific Research Volume-7 \| Issue-3 \| March-2018	PubMed, Index Copernicus, Google Scholar, Research Gate, ICI, ICMJE, Open J- Gate, INDIANScience.in, ISI, Cite Factor	2018
28	Definition of Terms Used in Limitation of Treatment and Providing Palliative Care at the End of Life: The Indian Council of Medical Research Commission Report	Naveen Salins Shivakumar Iyer etal	Indian J Crit Care Med. 2018 Apr; 22(4): 249–262	PubMed, Pro Quest, EMBASE, Scopus, EBSCO, HINARI, Google Scholar, ESCI	2018
29	PRactice of VENTilation in Middle- Income Countries (PRoVENT-iMIC): rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia	Luigi PisaniSS Iyer etal,	BMJ Open 2018; 8: e020841. doi:10.1136/ bmjopen-2017-020841	PubMed Central, Web of Science Core Collection: Science Citation Index Expanded, MEDLINE (Index Medicus), , Scopus, Embase (ExcerptaMedica), DOAJ, Google Scholar	2017
30	Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future	Schultz , Iyer SS etal	Intensive Care Med. 2017 May;43(5):612-624	PubMed/Medline, Science Citation Index/Journal Citation Report	2017
31	Near-Peer Teaching Program for First Year Residents in Medicine	Krishna,K etal, Iyer S , Jedge P.	South-East Asian Journal Of Medical Education Vol.11,no. 1, 2017	IMSEAR, Google Scholar, ResearchBib, Free Medicus, Open Science Directory. DRJI, ICMJE	2017
32	Withholding and withdrawal of life sustaining treatments in low middle income versus high income Asian countries and regions	J Phua etal, Dr. Jignesh Shah.(Collaborator )“	Intensive Care Med. 2016 Jul; 42(7):1118-27.	PubMed/Medline, Science Citation Index/Journal Citation Report	2016
33	Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome	Sameer Jog,  ShirishPrayag,  Prasad Rajhans,  Kapil Zirpe,  Subhal Dixit,  LalithaPillai, Jignesh Shah etal	Intensive Care Med 2015 Nov;41(11):2029-30	PubMed	2015
34	Comparison of Conventional and Simulation-based Teaching Methods in Blood Pressure Measurement	GR Godbole, EC Sada, S Iyer, AR Josh	Journal of Research in Medical Education & Ethics5(2):176		January 2015
35	Ten major priorities for intensive care in India	JVDivatia ,  Shivakumar Iyer	Intensive Care Med	PubMed	Aug 2015

Research works published as textbook chapters

Sr. NO	Book Name	Chapter Name	Author Name
1	Workbook on Renal Replacement Therapy in ICU	Drug Dosing on Renal Replacement Therapy	Jignesh Shah, Vishwanath Patil
2	Case-based Review in Critical Care Medicine	Acute Exacerbation of Chronic Obstructive Pulmonary Disease	Jignesh Shah et al
3	Critical Care Update 2019	End of life Practices in India : An update	Shivakumar Iyer, Jignesh Shah
4	Critical Care Medicine MCQs Practice Book 2nd Edition	End of Life / Ethics / Transplant	Jignesh Shah Moturu Dharanindra
5	Critical Care Medicine MCQs Practice Book	Renal Fluids and Electrolytes	Shivakumar Iyer / Dharanindra Moturu
6	Yearbook of Anesthesiology- 8	End of Life care in India: Problems and Solutions	Raj Kumar Mani, Shivakumar Iyer
7	Textbook of CRITICAL CARE Including Trauma and Emergency Care	Approach to Unconscious Patient	Shivakumar Iyer, Jignesh Shah
8	Workbook on Hemodynamic Management	Managing Hypertensive Emergencies and Crisis	Jignesh Shah, Prashant Jedge
9	Critical Care Update 2018	Value of the Anion Gap in Critical Illness	Shivakumar Iyer
10	Principles of Critical Care in Obstetrics	Respiratory Monitoring and blood gas physiology	Shivakumar Iyer, Jignesh Shah
11	Critical Care Update 2017	Ethical issues in Resource Allocation for Critical Care in Resource-Limited Countries	Shivakumar Iyer
12	Medicine update 2016-2	Scoring System in Critically ill: Does it help in Prognostication	Shivakumar Iyer, Jignesh Shah
13	Textbook of Emergency Medicine	Mechanical Ventilation	Shivakumar Iyer, Jignesh Shah
14	Clinical Medicine Update (Vol XV)	Antibiotic use in an intensive care setting	Jignesh Shah
15	Critical Care Update 2010	Serotonin Syndrome	Shivakumar Iyer, Jignesh Shah
16	Basics of Clinical Nutrition	Nutrition and Cardiovascular Disease	Shivakumar Iyer
17	ICU PROTOCOLS A Stepwise Approach	Acute febrile Encephalopathy	Shivakumar Iyer, Jignesh Shah
18	ICU PROTOCOLS A Stepwise Approach	Subarachnoid hemorrhage	Shivakumar Iyer, Jignesh Shah Kiran Vadapalli
19	ICU PROTOCOLS A Stepwise Approach	Coma	Shivakumar Iyer, Kayanoosh Kadapatti

Collaborations

The Department of Critical Care Medicine, Bharati Vidyapeeth Deemed to be University Medical College, along with the Department of Public Health, Government of Maharashtra has decided to conduct an Acute care training program for Covid 19 in collaboration with JHPEIGO and DGHS, Maharashtra.

MAHA-ACT”, Acute Care Training Program

Ongoing Activities

MAHA –ACT: Acute care training (COVID) program in collaboration with Government of Maharashtra and JHPIEGO
Solidarity Plus trials
Investigator-initiated studies