Herbal Medicine

Research Projects

Sr.No Type Year Funding Agency Status
  Fellowship Sponsored
1 Development and evaluation of new synbiotic formulation for gut-inflammation 2022 Onwords UGC - SRF  Ongoing
2 Chemometric analysis and Development of Methodology for quality standardization of ‘Vidanga’ 2017-2022 CSIR-HRDG- SRF Completed
3 Chemical diversity and nutraceutical potential of Indian Propolis 2016-2017 Department of Science and Technology (DST)-Science & Engineering research Board (SERB) Completed
1 Studies on new symbiotic formulation with special reference to gut inflammation 2022-2023 BVDU/IRSHA Ongoing
2 Evaluation of heavy metal accumulation in selected medicinal plants 2022-2023 BVDU/IRSHA Ongoing
3 Anti-inflammatory and Immunomodulatory Activity of Synbiotic Formulation against Intentional Inflammation 2021-2022 BVDU/IRSHA Completed
4 Toxicity studies on bulbils of D. bulbifera L. 2016-2017 BVDU/IRSHA Completed


Chemical diversity and nutraceutical potential of Indian Propolis

Propolis is a resinous material that honey bees collect from plant sources. Consequently, its chemical composition varies with region and season. It has lot of applications in pharmaceutical and nutraceutical preparations due to their wide range of bio-activities. However, its inconsistent chemical composition is the biggest hurdle in maintaining its quality for commercial purposes. India has good apiculture setup but byproducts are not commercially explored.


Toxicity studies on bulbils of D. bulbifera L.

Medicinal plants generally considered as safe without any effects. But some of recent studies on many medicinal plants commonly used traditional system of medicine displayed adverse effects when given as overdose (Koduru et al., 2006; Wonder et al., 2011). Therefore, potential toxic effects of medicinal plants due to their short-term or prolonged use should be taken into consideration for its medicinal use in development of pharmaceuticals. Toxicity studies in appropriate animal models allow assessing potential health risks in humans. Such toxicity studies assess the hazard and determine the risk level by addressing the probability of exposure to that particular hazard at certain doses or concentrations (Bello et al., 2016). According to World Health Organization, for safety evaluation of herbal or traditional medicinal products several countries have developed their own national regulations (World Health Organization, 1998; World Health Organization, 2000). There are different test methods advised by the Organization for Economic Co-operation and Development (OECD) for evaluation of toxicity profiles (OECD guideline, 2001a; 2001b; 2001c).

Development and evaluation of a new synbiotic formulation for gut inflammation

The culmination of this research is to uncover the mechanisms by which diet can improve gut microflora and, in turn, may decrease inflammation. When the human microbiome is challenged with changes in diet, stress, or antibiotics, the physiology of the regular microbiome changes. Pro/pre/synbiotics-based therapies are considered a gate for the modulation of gut flora regarding gut inflammation. Usually, foodstuffs rich in dietary fibre serve as prebiotic sources. Such as cereals, fruits, nuts, & tuberose vegetables etc. This study will use tuberous plants as a source of prebiotic and different probiotic strains to form a synbiotic formulation which will be further administrated in different models (Rat model) to prove its efficacy against gut inflammation

Sr.no Name Ph. d. Project Status
1 Mr. Manoj Khawate Chemometric analysis and Development of Methodology for quality standardization of ‘Vidanga’ Ongoing
2 Mr. Mayur Aswani Development and evaluation of new synbiotic formulation against candidal inflammation of intestine Ongoing
3 Mr. Kartikey Jagtap Exploring ‘Vidanga’ (Embelia spp.) and its substitute with respect to its pharmacological activities Ongoing
4 Mr. Suraj Bhongale Comparative study of various species of indian Yam (Genus Dioscorea) with respect to their Pharmacological and nutraceutical potential Ongoing
5 Ms. Apurva Jadhav Development and Evaluation of New Synbiotic Formulation for Gut Inflammation Ongoing
6 Mr. Mahesh Ekbote Chemometric analysis and development of methodology for quality standardization of 'Haritaki' (Terminalia chebula Retz.) Ongoing
7 Mr. Shrikant Thopate Exploring different varieties of ‘Haritaki’ (Terminalia chebula) with respect to its pharmacological activities Ongoing

Ph.D Projects :

Exploring ‘Vidanga’ (Embelia spp.) and its substitute with respect to its pharmacological activities

‘Vidanga’ is one of the herbs commonly used in Ayurveda. It is considered to support the intestine to keep the digestive system healthy. There several local names for ‘Vidanga’ and are known for their medicinal use for thousands of years. ‘Vidanga’ has a strong traditional as well as an experimental base for its use such as in skin ailments like acne and pimples, in constipation, digestive track in piles, as a brain tonic, etc. Taxonomically, all the species under the name ‘Vidanga’ belong to the genus Embelia and Maesa of the family Myrsinaceae. Four species are Embelia ribes Burm.f., E. tsjeriam-cottam (Roem. & Schult), E. drupacea (Dennst.) M.R. Almeida & S.M. Almeida and Maesa indica (Roxb.) A.DC. There is confusion in market samples of 'Vidanga' as they are available single or in mixtures of allied species, hence there is an ambiguity in the identification of authentic drug as 'Vidanga' and considering the utmost condition, related parameters will be studied to find out most potent species from the genus Embelia & Maesa as a drug Vidanga.

Chemometric analysis and Development of Methodology for quality standardization of ‘Vidanga ’

Plants synthesize a bulk amount of secondary metabolites or bioactive principles which are accountable for the therapeutic activities of medicinal plants and provides unlimited opportunities for new drug leads. Herbal medicines would be accepted readily for treatment only if they could successfully pass through a full regimen of standardization parameters, which requires safety and efficacy data. Pharmacologically active components or biomarkers are currently employed for evaluating the quality and authenticity of herbal medicines. Metabolic fingerprinting of complex biological and herbal samples has the potential to enhance the quality, safety, and efficacy of herbal medicine by providing a comprehensive view of a multitude of quality-determining compounds. Considering the demand for drug ‘Vidanga’, the potential to cure a variety of diseases, and ambiguity in supply of the authentic drug in the market, its chemometric study is essential. Therapeutic properties of the genus Embelia are attributed by Embelin or Embolic acid present in berries of plants which is a major secondary metabolite. Recent advances in chemometrics to identify markers compounds and chemometrics by standardization can be applied for ‘Vidanga’ to create biomarker based identification of the genuine drug.

Development and evaluation of new synbiotic formulation against candidal inflammation of intestine

Prebiotics have been discussed with respect to the systemic effects they exert on the host’s health, metabolism, and immune system. The ability to regulate the composition of the gut microbiota by prebiotic dietary substances and probiotic microorganisms is an interesting approach in the control and treatment of some major diseases. Prebiotics are emerging as promising nutraceuticals in various medical conditions, including IBD. Since prebiotics are easy to administer, inexpensive, and lack significant toxic side effects they may become an attractive alternative or adjunct to standard therapeutics in inflammation conditions. Hence, here we are studying wild and organic vegetables as a potential source as prebiotics which in combination with probiotics will lead to the development of probable symbiotic formulations.