Maternal Nutrition and Child health

The theme of our research is suboptimal maternal nutrition during critical periods of development influences developmental pathways.

  • Which leads to changes in placental structure, gene expression patterns and physiological functions
  • Thus increases the risk for adverse pregnancy outcomes (Hypertensive Disorders of Pregnancy, Preterm birth, Low Birth Weight, Gestational Diabetes)
  • Leading to Increased Risk for Non-Communicable Diseases (NCDs) in Later Life
  • Our department focuses on both human and animal studies
maternal nutrition
maternal nutrition

Human Studies

  • Our department has established a cohort of ~2500 pregnant women (normal; hypertensive; preterm and gestational diabetes) which were followed across the pregnancy
  • Maternal blood, placenta and cord samples were collected for biochemical and epigenetic assessments
  • Maternal information on sociodemographic characteristics, clinical history, anthropometry, nutritional intakes and physical activities were collected¬†
  • After delivery children of these mothers were also followed till adolescence for anthropometry and cognitive assessments

Animal Studies

  • Animal models are also used to validate and understand role of maternal nutrition and mechanisms leading to fetal programming for adult diseases
  • Animals are used to understand epigenetic pathways, risk of diseases and their cognitive performances

Expected Outcome

  • Determining the link between maternal nutrition, pregnancy outcome and cardiometabolic and neurodevelopmental risk in children at adult age
  • Identification of biomarkers to determine risk for adverse pregnancy outcome
  • Provide clues for supplementation for better pregnancy outcome / for reducing risk for diseases