DBT – SAHAJ Infrastructure Programme

Overview

Objectives

Objectives

To establish a facility for lipidome and methylation analysis from various biological samples
To examine the lipidome and methylation patterns in women with preeclampsia and its association with CVD risk
To undertake training programmes and provide service for academia and industry

Study Design

Proposed Facility and Need

Proposed Facility

High Performance Benchtop Orbitrap LC-MS 240 system: lipidome analysis

It will help to gain an in-depth understanding of the role of lipids (which account for over 100 lipid molecules) and its association with CVD risk

Pyrosequencer

DNA methylation analysis of genes involved in the lipid metabolism and its association with CVD risk

Need for the Proposed Facility

Few lipidome/pyrosequencing facilities in India – limited availability and expensive
Facilities do not undertake lipidome analysis on clinical samples
Human cohort samples are very precious and have biosafety issues
IRSHA has established good quality and biosafety systems
There is a pressing need to develop this facility to better understand the role of lipids in diseases

Impact

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Award

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Admission
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