Dr. Kalimuthu KalishwaralalAssistant Professor
Bharati Vidyapeeth, Pune
Department : Cancer Biology, IRSHA, BVDU, Pune
Date of Birth : 07/05/1986
Designation : Assistant Professor
Department/Institute/University : Cancer Biology, IRSHA, BVDU, Pune
Phone : 020-24366920/ 9787619623
Education : B.Tech., M.Tech., PhD. Biotechnology
Area of Interest
-
Exploring the Role of Selenoprotein P in Cancer Progression and Type 2 Diabetes
-
Phage Display-Based Peptide Discovery and Its Application in Peptide–Drug Conjugation
-
Investigating Cell Death Signalling Pathways: Ferroptosis, Cuproptosis, and Apoptosis
Research Experience
-
MK Bhan Young Researcher, Rajiv Gandhi Centre for Biotechnology (RGCB),
Kerala, India (2021- 2025)
-
Postdoctoral Researcher, Jeonbuk National University, South Korea (2021- 2021).
-
Postdoctoral Research Associate, University of Pittsburgh, USA(2019- 2020).
-
Postdoctoral Fellow, Konkuk University, South Korea (2018–2019).
-
Postdoctoral Fellow, Ariel University, Israel(2016-2018).
Projects
-
Project Title: Pre-clinical evaluation of the mechanistic and immunological pharmacodynamics of a novel saponin, Uttroside-B (Utt-B) ,against Heptocellular carcinoma (HCC)
Funding agency: DBT-MK Bhan Young Research Fellowship
Duration: 2021 – 2025
Role: Principal -Investigator
-
Project Title: Development of a novel herbal mineral water formulation using Solanum nigrum Linn fruit a pilot study
Funding agency: DST –Young Scientist and Technologist
Duration: 2024 – 2025
Role: Principal -Investigator
Honors/Awards
-
MK Bhan Young Researcher fellowship – Department of Biotechnology, Government of India.(2021)
-
Awarded Senior Research Fellow (SRF) from Council for Scientific and Industrial Research (CSIR), Govt. of India. (Individual fellowship)(2010)
-
Best Poster Award at International conference on Nanobiotechnology at CCMB, India(2008)
-
B.Tech Project work awarded and funded by Tamilnadu State Council for Science and Technology (TNSCST) – under Students Project Scheme.(2007).
PERFORMANCE INDICATORS
Source: google scholar :
Kalishwaralal kalimuthu - Google Scholar
PROFESSIONAL TRAINING
-
Six month training in Montpellier Cancer Research Institute, Montpellier, Frances under the guidance of Eric vives – (Peptide synthesis, nanoparticles synthesis, peptide nanoparticles complex formation)
-
Undergone short term training programme on 5th DST Advanced School on Nanoscience and Nanotechnology for 7 days at Indian Institute of Sciences (IISC), Bangalore, India.
Research Publications
Research publications in peer reviewed journals (Last Five year) (*-Corresponding Author)
- 1. Kalishwaralal, K*., Nazeer, A.A., Induja, D.K., Keerthana, C.K., Shifana, S.C. and Anto, R.J., 2024. Enhanced extracellular vesicles mediated uttroside B (Utt-B) delivery to Heptocellular carcinoma cell: Pharmacokinetics based on PBPK modelling. Biochemical and Biophysical Research Communications, p.149648.(IF: 3.1) (SCI index)
-
Rossan Mathews, M.G., Subramaniam, R., Venkatachalam, S., Selvan Christyraj, J.R.S., esudhason, B.V., Kalimuthu, K., Mohan, M. and Selvan Christyraj, J.D., 2024. Biochemical and functional characterization of heat-inactivated coelomic fluid from earthworms as a potential alternative for fetal bovine serum in animal cell culture. Scientific Reports, 14(1), p.5606.(IF:4.6) (SCI index)
-
Rajagopalan, K., Selvan Christyraj, J.D., Chelladurai, K.S., Kalimuthu, K., Das, P., Chandrasekar, M., Balamurugan, N. and Murugan, K., 2024. Understanding the molecular mechanism of regeneration through apoptosis-induced compensatory proliferation studies updates and future aspects. Apoptosis, pp.1-16.(IF:7.2) (SCI index)
-
Kalishwaralal, K*., Abhishek, A., Keerthana, C.K., Rayginia, T.P., Swetha, M., Aiswarya, S.U., Arivalagan, J., Bava, S.V., Firer, M.A. and Anto, R.J., 2023. Selenium Metabolic Pathway in Ferroptotic Cell Death. In Ferroptosis in Health and Disease (pp. 369-382). Cham: Springer International Publishing.
-
Shahbazi, R., Kalishwaralal, K*., Paul, M.K. and Anto, R.J., 2023. Role of Extracellular vesicles (EVs) in pathogenesis, diagnosis, therapeutic delivery, treatment, and theranostic applications in Cancer. Frontiers in Bioengineering and Biotechnology, 11, p.1288806. (IF: 5.7) (SCI index)
-
Rathore, A.S., Gupta, K.K., Govindaraj, S.K., Ajmani, A., Arivalagan, J., Anto, R.J.,
Kalishwaralal, K*. and Chandran, S.A., 2023. Targeting BRF2: insights from in silico screening and molecular dynamic simulations. Journal of Biomolecular Structure and Dynamics, pp.1-13. (IF: 4.4) (SCI index)
-
Arivalagan, J., Ganapathy, A., Kalishwaralal, K., Chen, Y. and George, A., 2023. Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues. Biomolecules, 13(3), p.412.(IF: 6.01) (SCI index)
-
Ganesan M, Selvan Christyraj JR, Venkatachalam S, Yesudhason BV, Chelladurai KS, Mohan M,Kalimuthu K, Narkhede YB, Christyraj JD. Foldscope microscope, an inexpensive alternative tool toconventional microscopy—Applications in research and education: A review. Microscopy Researchand Technique. 2022 Jul 25. (IF: 2.8) (SCI index)
-
Ramakrishnan M, Arivalagan J, Satish L, Mohan M, Christyraj JR, Chandran SA, Ju HJ, Ramesh T,Ignacimuthu S, Kalishwaralal K. Seleniums role in ferroptosis and biomass production.Chemosphere. 2022 Jun 30:135531. (IF:8.9)* (SCI index)
-
Kalimuthu, Kalishwaralal, Jaison Arivalagan, Manikandan Mohan, Johnson Retnaraj Samuel Selvan Christyraj, Jesu Arockiaraj, Ramakrishnan Muthusamy, and Ho-Jong Ju. "Point of care diagnosis of plant virus: Current trends and prospects. Molecular and cellular probes 61 (2022): 101779 ( IF-2.38)
-
Kalimuthu, Kalishwaralal, Chenicheri K. Keerthana, Manikandan Mohan, Jaison Arivalagan, Johnson Retnaraj Samuel Selvan Christyraj, Michael A. Firer, Mohammad Haroon Asif Choudry, Ruby John Anto, and Yong J. Lee. "The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer. Journal of Cellular Biochemistry. (IF-.4.42) (2021)
-
Kalimuthu, Kalishwaralal, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M. Haroon A. Choudry, and Yong J. Lee (2021).Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Journal of Cellular Physiology .236 (9) 6666-6677 (IF-6.38).
-
Saravanan, Muthupandian, Ebrahim Mostafavi, Savariar Vincent, Hadush Negash, Rajapriya Andavar, Venkatesan Perumal, Namas Chandra, Selvaraju Narayanasamy, Kalishwaralal Kalimuthu, and Hamed Barabadi(2021). Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19. Microbial pathogenesis 104908 (IF-3.73).
-
Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Xu Luo, M. Haroon A.Choudry, David L. Bartlett, and Yong J. Lee.(2020) BAX-dependent mitochondrial pathway mediates the crosstalk 1 between ferroptosis and apoptosis. Apopotosis. 25 (9), 625-631 (IF-4.1)
- Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Hima Makala, Simon C. Watkins, M. Haroon A. Choudry, David L. Bartlett, Yong Tae Kwon, Yong J. Lee. (2020) Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome. Journal of Cellular Physiology. DOI : doi.org/10.1002/jcp.29571. (IF-6.38)
- Kalishwaralal Kalimuthu, Byung Seok Cha, Seokjoon Kim, and Ki Soo Park (2020), "Eco-friendly synthesis and biomedical applications of gold nanoparticles: A review", Microchemical Journal.152,104296. (IF=3.206)
- Woo Young Kwon, Byung Seok Cha, Seokjun Kim,a Sung Hyun Hwang,a Jimin Kim, Kalishwaralal Kalimuthu, Hyun Gyu Parkb and Ki Soo Parka.(2019) Fluorescence polarization- based detection of cancer-related mutations using target-initiated rolling circle amplification. Analyst. 144, 4149. (IF-3.8)
- Kalishwaralal Kalimuthu, Woo Young Kwon ,Ki Soo Park.(2019) A simple approach for rapid and cost-effective quantification of extracellular vesicles using a fluorescence polarization technique. Journal of Biological Engineering. 13:31.(IF- 5.256)
- Hyunmin Eun, Woo Young Kwon, Kalishwaralal Kalimuthu, Yonghwan Kim, Miran Lee, Jung-Oh Ahn, Hongweon Lee, Sang Hyun Lee, Hyung Joo Kim, Hyun Gyu Park, and Ki Soo Park.(2019) Melamine-promoted formation of bright and stable DNA-silver nanoclusters and their antimicrobial properties. Journal of Materials Chemistry B. 7, 2512. (IF=4.776)
- Kalimuthu Kalishwaralal ,Woo Young Kwon ,Ki Soo Park.(2019) Exosomes for non-invasive cancer monitoring. Biotechnology Journal. 14(1):e1800430. (IF- 3.507)
- Kalishwaralal Kalimuthu, Bat-Chen Lubin, AndriiBazylevich, Gary Gellerman., Ofer Shpilberg, Galia Luboshits and Michael A. Firer. (2018) Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. Journal of Nanobiotechnology. 16:34 (IF- 5.2)
- Kalimuthu Kalishwaralal, Subhaschandrabose Jeyabharathi, Krishnan Sundar, Sethuraman Selvamani, Mahendran Prasanna, Azhaguchamy Muthukumaran.(2018) A novel biocompatible Chitosan–Selenium Nanoparticles (SeNPs) film with electrical conductivity for cardiac tissue engineering application. Materials Science and Engineering: C 92:151-160. (IF-5.0)
- SubhaschandraboseJeyabharathi,KalimuthuKalishwaralal,KrishnanSundar,AzhaguchamyMuthu kumaran. (2017) Synthesis of zinc oxide nanoparticles (ZnONPs) by aqueous extract of Amaranthus caudatus and evaluation of their toxicity and antimicrobial activity. Materials Letters.209,295-298. (IF-2.68)
- Devi GK, Kumar KS, Parthiban R, Kalishwaralal K.(2017) An insight study on HPTLC fingerprinting of Mukia maderaspatna: Mechanism of bioactive constituents in metal nanoparticle synthesis and its activity against human pathogens. Microbial pathogenesis 102,120-132. (IF- 2.3)
- KalimuthuKalishwaralal , SubhaschandrabosJeyabharathi ,KrishnanSundar ,Azhaguchamy Muthukumaran.(2017) Mapping of accumulation of SeNPs in developing zebrafish embryos and larvae: a new method using SEM with energy dispersive X-ray spectrometer. Micro & Nano Letters.12,497-499. (IF-0.841)
- Kalimuthu Kalishwaralal, Subhaschandrabose Jeyabharathi, Krishnan Sundar, and Azhaguchamy Muthukumaran. (2016). Comparative analysis of cardiovascular effects of selenium nanoparticles and sodium selenite in zebrafish embryos. Artificial cells, nanomedicine, and biotechnology 1-7. (IF- 3.02)
- Kalimuthu Kalishwaralal, Subhaschandrabose Jeyabharathi, Krishnan Sundar, and Azhaguchamy Muthukumaran. (2016). A novel one-pot green synthesis of selenium nanoparticles and evaluation of its toxicity in zebrafish embryos. Artificial cells, nanomedicine, and biotechnology, 1-7. (IF- 3.02)
- Kalimuthu Kalishwaralal, Subhaschandrabose Jeyabharathi, Krishnan Sundar, and Azhaguchamy Muthukumaran. (2015). Sodium selenite/ Selenium Nanoparticles (SeNPs) protect cardiomyoblasts and zebrafish embryos against ethanol induced oxidative stress. Journal of Trace Elements in Medicine and Biology. 32:135-144. (IF- 3.75)
PROFESSIONAL SOCIETY MEMBERSHIP
Biotech Research Society, India.