Department : Cancer Research Lab, IRSHA, BVDU, Pune
Date of Birth : 21/11/1983
Designation : Associate Professor
Department/Institute/University : Cancer Research Lab, IRSHA, BVDU, Pune
Phone : 020-24369920 (ext. 212 / 204)
Education : M. Pharmacy, Ph.D. (Pharmaceutical Biotechnology).
Area of Interest
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Cancer Biology & Medicine
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Cancer Metastasis & Therapeutics
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Drug Discovery
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Translational Research
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Pharmaceutical Biotechnology
Research Experience
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Associate Professor & Head, Cancer Research Lab, Interactive Research School for Health Affairs (IRSHA), BVDU, Pune (Sep 2023 – Till date).
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Scientist & Head, Cancer Research Lab, Interactive Research School for Health Affairs (IRSHA), BVDU, Pune (Nov 2022 – Aug 2023).
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Scientist, CINHD, Interactive Research School for Health Affairs (IRSHA), BVDU, Pune (March 2022 – Nov 2022).
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Data Analyst (Subject Matter Expert), Medical Writing (Manuscript Writing), Cognizant Technology Solutions India Private Limited, Mumbai, Maharashtra (Oct 2021 – March 2022).
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Research Associate-III (Domain Analyst), MANAV: Human Atlas Initiative, National Centre for Cell Science (NCCS), Pune (Aug 1019 – Oct 2021).
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Junior Scientist, CINHD, Interactive Research School for Health Affairs (IRSHA), BVDU, Pune, Maharashtra (July 2015 - July 2019).
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Senior Research Fellow, CINHD, Interactive Research School for Health Affairs (IRSHA), BVDU, Pune, Maharashtra (May 2012 - June 2015).
Honors/Awards
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Research Associate-III on MANAV: Human Atlas Initiative at National Centre for Cell Science (NCCS), Pune, Maharashtra (2019-2021).
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Featured as the cover image for Cancer Biology & Medicine Volume 15, Issue 2 in 2018, showcasing a notable impact on the field with a selected confocal image.
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National Agricultural Innovation Project (NAIP)-III Senior Research Fellowship at IRSHA, Pune, Maharashtra, in 2012.
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Approval for the appointment as a Lecturer in Pharmaceutics by the University of Pune, serving from 2008 to 2011.
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Honored as a 'Dhirubhai Ambani Scholar' and recipient of the 'Dhirubhai Ambani Undergraduate Scholarship' in 2002.
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Recognition from the Social Welfare Department of Maharashtra for academic achievement in the HSC exam.
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Top Rank Acknowledgment from Maharashtra State Board for academic achievement in HSC exam.
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Peer reviewer for a journal “Drug Metabolism & Personalized Therapy”, Walter de Gruyter GmbH, Germany.
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Peer reviewer for a journal “Current Pharmacology Reports”, Springer International Publishing AG, Switzerland.
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Peer reviewer for the journal “Frontiers in Pharmacology”, Frontiers Media S.A., Switzerland.
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A member of the Scientific Committee at Bharati Vidyapeeth (Deemed to be University), Homoeopathic Medical College & Hospital, Dept. of Post-graduate and Research Center, Pune, Maharashtra (from 2023-24 to 2025-26).
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Vice-president of Institution’s Innovation Council- Interactive Research School for Health Affairs (IRSHA), BVDU, Pune.
Research Program
Our cutting-edge research program is dedicated to unraveling the intricate biology of cancer, particularly the metastatic cascade. We focus on understanding the molecular events that drive cancer spread, aiming to contribute valuable insights to the field of cancer research and treatment.
Research Focus : Understanding Molecular Pathology of Metastasis
Our primary objective is to comprehend the molecular pathological events governing metastasis, including Epithelial-Mesenchymal Transition (EMT), Extracellular Matrix (ECM) remodeling, Intravasation, Survival in the circulation, Extravasation, Colonization, and the acquisition of a cancer stem cell phenotype. By dissecting these processes at the cellular and molecular levels, we strive to identify key molecular players and vulnerabilities within the metastatic cascade.
In-Depth Investigations : In-Vitro Cell Culture and Molecular Biology Studies
Our research program employs rigorous in-vitro cell culture and molecular biology studies to simulate the intricate microenvironment within the human body. By meticulously studying cancer cells in this context, we gain nuanced insights into the molecular events driving metastasis. This approach bridges the gap between benchside research and the clinical reality of cancer patients, offering a more translational perspective.
Systems Biology Integration : Network Pharmacology and Bioinformatics
In addition to traditional approaches, we embrace systems biology methodologies, specifically network pharmacology and bioinformatics. This integrative approach allows us to decipher complex molecular signaling pathways and identify targets associated with the molecules under study. Through a systems-level understanding, we enhance the precision and effectiveness of our therapeutic strategies.
Antimetastatic Therapeutics : From Bench to Bedside
Central to our mission is the identification of potential drug targets to formulate antimetastatic therapeutics. We explore diverse sources, including plant-based small molecules, nutritional compounds, and promising drug candidates. This multifaceted approach aims to provide a comprehensive arsenal against metastasis, addressing the complexities of its various stages.
As we strive to advance the frontiers of cancer research, our research program is poised to make transformative contributions to the field. By unraveling the complexities of metastasis and developing targeted therapeutics, we aim to redefine the landscape of cancer treatment, offering hope and improved outcomes for patients worldwide. Stay connected as we navigate the intricate terrain of cancer biology and work towards a future where our discoveries pave the way for personalized and effective cancer therapies.
Publications
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International Publications: 11
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Book Chapters: 4
Research Publications
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Mali A. V., Padhye S., Anant S., Hegde M.V., Kadam S.S. (2019). Anticancer and antimetastatic potential of enterolactone: Clinical, Preclinical and Mechanistic Perspectives, European Journal of Pharmacology, 852, 5 June, 107-124.
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Mali, A. V., Joshi, A. A., Hegde, M. V., & Kadam, S. S. (2018). Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition. Cancer Biology & Medicine, 15(2), 137-156.
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Mali, A. V., Bhise, S. S., Katyare, S. S., & Hegde, M. V. (2018). Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis. Indian Journal of Clinical Biochemistry, 33(1), 38-45.
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Mali, A. V., Joshi, A. A., Hegde, M. V., & Kadam, S. S. (2017). Enterolactone Suppresses Proliferation, Migration and Metastasis of MDA-MB-231 Breast Cancer Cells Through Inhibition of uPA Induced Plasmin Activation and MMPs-Mediated ECM Remodeling. Asian Pacific journal of cancer prevention: APJCP, 18(4), 905.
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Mali, A. V., Bhise, S. S., Hegde, M. V., & Katyare, S. S. (2016). Altered erythrocyte glycolytic enzyme activities in type-II diabetes. Indian Journal of Clinical Biochemistry, 31(3), 321-325.
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Hegde, M. V., Mali, A. V., & Chandorkar, S. S. (2013). What is a cancer cell? Why does it metastasize? Asian Pacific Journal of Cancer Prevention, 14(6), 3987-3989.
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Mali, A. V., Wagh, U. V., Hegde, M. V., Chandorkar, S. S., Surve, S. V., & Patole, M. V. (2012). In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. Indian journal of cancer, 49(1), 181.
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Mali, A. V., Dhavale, R. P., Mohite, V. L., Mahindrakar, A. R., Pore, Y. V., & Kuchekar, B. S. (2006). Spectrophotometric estimation of Gatifloxacin in tablets. Indian journal of pharmaceutical sciences, 68(3), 386.
Book Chapters
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Katyare SS, Mali AV. Omega-3 Fatty Acids and Mitochondrial Functions. In Omega-3 Fatty Acids 2016 (pp. 229-233). Springer International Publishing.
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Mali AV, Bhise SS, Katyare SS. Omega-3 Fatty Acids and Diabetic Complications. In Omega-3 Fatty Acids 2016 (pp. 221-227). Springer International Publishing.
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Mali A., Sawant A., Mahadik A., Nair S. (2021) Immunotherapy for Autoimmune Diseases. In: Sawarkar S.P., Nikam V.S., Syed S. (eds) Immunotherapy – A Novel Facet of Modern Therapeutics. Springer, Singapore. http://doi-org-443.webvpn. fjmu.edu.cn/10.1007/978-981-15-9038-2_4.
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Rohit Godbole, Asha Goutam, Aniket Mali*. Microbial Biopolymers: Medical, Pharmaceutical & Biotechnological Applications. In: Vaishnav A., Choudhary D.K. (eds) Microbial Polymers. Springer, Singapore. https://doi.org/10.1007/978-981-16-0045-6_18