Profile
Teaching Experience: 10 Years
Research Experience: 15 Years
Institute Email ID: maruti.dhanavade@bharatividyapeeth.edu
Personal Email ID: marutijd@gmail.com
LinkedIn Link: www.linkedin.com/in/dr-maruti-dhanavade-813a2962
SCOPUS Link: https://www.scopus.com/authid/detail.uri?authorId=55617335500
ORCID Link: https://orcid.org/0000-0002-8375-0928
Research Gate Link: https://www.researchgate.net/profile/Dr-Maruti-Dhanavade
Google Scholar Link: https://scholar.google.com/citations?user=PiBTnvEAAAAJ&hl=en
Vidwan Link: https://vidwan.inflibnet.ac.in/profile/362027
Profile (Bio): Dr. Maruti Jayram Dhanavade is Assistant Professor at Bharati Vidyapeeth (Deemed To be) University, Yashwantrao Mohite College of Arts, Science and Commerce, Pune. He is a faculty in Department of Microbiology.
Summary of My Research Work
I completed my PhD in Microbiology (March 2016) at Shivaji University, Kolhapur, focusing on the degradation of amyloid-beta (Aβ) peptides using microbial enzymes—an important approach toward Alzheimer’s disease therapeutics. My work primarily explored the proteolytic mechanism of the aminopeptidase SGAK from Streptomyces griseus KK565 through computational methods such as molecular docking and molecular dynamics simulations. These studies helped identify key amino acid residues involved in Aβ recognition and enabled the proposal of a novel catalytic mechanism for Aβ degradation, published in Amino Acids.
I also investigated the role of a cysteine protease from Xanthomonas campestris in Aβ peptide degradation, published in Computers in Biology and Medicine, where the article ranked 21st among the top 25 hottest searched papers in 2014. Additionally, I isolated Streptomyces regensis MK and demonstrated that its purified aminopeptidase efficiently degrades Aβ peptides, and this work is ready for communication.
Overall, my research integrates molecular-level computational analysis and experimental validation to understand enzyme–substrate interactions in Aβ degradation. I have also contributed a book chapter on molecular docking techniques in an international edited volume. To date, I have published 53 research papers and hold 2 patents.
Future Directions
My future research aims to advance computational biology and drug design by discovering and validating novel therapeutic molecules using bioinformatics tools along with experimental approaches. I am particularly interested in using molecular docking, MD simulations, enzyme purification, and protein–ligand interaction studies to unravel disease mechanisms and design targeted drugs.
